4-(2-Piperidyl)-1, 3-dioxolanes with Local Anesthetic, Spasmolytic, and Central Nervous System Activity1

WR Hardie, J Hidalgo, IF Halverstadt…

文献索引：Hardie,W.R. et al. Journal of Medicinal Chemistry, 1966 , vol. 9, p. 127 - 136

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被引用次数: 36

摘要

Method B: R1R2C0+ R1RzCC12-R1R2C (OCHa) 2 acetals (Table I) were found to be free of ketones, as shoxm by the absence of infrared absorption in the carbonyl band, except for 5 and 8 which nonetheless gave satisfactory yields of dioxolanes. The vicinal glycol was obtained by hydrogenating (2-pyridyl)-1, 2-ethanediol hydrochloride12 (I) in water, acetic acid, or methanol using platinum oxide catalyst to give (2-piperidyl)-1, 2-ethanediol ...