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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists

…, S Hinuma, K Kato, H Nishikawa, K Hirai…

文献索引：Uchikawa, Osamu; Fukatsu, Kohji; Tokunoh, Ryosuke; Kawada, Mitsuru; Matsumoto, Kiyoharu; Imai, Yumi; Hinuma, Shuji; Kato, Koki; Nishikawa, Hisao; Hirai, Keisuke; Miyamoto, Masaomi; Ohkawa, Shigenori Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4222 - 4239

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被引用次数: 123

摘要

To develop a new therapeutic agent for sleep disorders, we synthesized a novel series of tricyclic indan derivatives and evaluated them for their binding affinity to melatonin receptors. In our previous paper, we proposed a conformation of the methoxy group favorable for the binding of the MT1 receptor. To fix the methoxy group in an active conformation, we decided to synthesize conformationally restricted tricyclic indan analogues with the oxygen atom in ...

2,3-二氢苯并呋喃结构式

2,3-二氢苯并呋喃

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2,3,5,6-四氢-7H-茚并[5,6-B]呋喃-7-酮结构式

2,3,5,6-四氢-7H-茚...

2,3-二氢苯并呋喃-5-甲醛结构式

2,3-二氢苯并呋喃-5-甲醛

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2,3,5,6-四氢-7H-茚并[5,6-B]呋喃-7-酮结构式

2,3,5,6-四氢-7H-茚...

(E)-3-(2,3-二氢苯并呋喃-5-基)丙烯酸结构式

(E)-3-(2,3-二氢苯并...

~%

2,3,5,6-四氢-7H-茚并[5,6-B]呋喃-7-酮结构式

2,3,5,6-四氢-7H-茚...

2,3-二氢-1-苯并呋喃-5-丙酸结构式

2,3-二氢-1-苯并呋喃-5-丙酸

~%

2,3,5,6-四氢-7H-茚并[5,6-B]呋喃-7-酮结构式

2,3,5,6-四氢-7H-茚...

6-甲氧基-1-茚满酮结构式

6-甲氧基-1-茚满酮

~%

(S)-N-[2-[7-烯丙基-5-溴-2,3-二氢-6-羟基-1H-茚满-1-基]乙基]丙酰胺结构式

(S)-N-[2-[7-烯丙基...

(2E)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)acetonitrile结构式

(2E)-2-(2,3-Dih...

~%

(S)-N-[2-[7-烯丙基-5-溴-2,3-二氢-6-羟基-1H-茚满-1-基]乙基]丙酰胺结构式

(S)-N-[2-[7-烯丙基...

(2E)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)ethanamine结构式

(2E)-2-(2,3-Dih...

~%

(S)-N-[2-[7-烯丙基-5-溴-2,3-二氢-6-羟基-1H-茚满-1-基]乙基]丙酰胺结构式

(S)-N-[2-[7-烯丙基...

(E)-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)ethyl]propanamide结构式

(E)-N-[2-(2,3-D...

~%

(S)-N-[2-[7-烯丙基-5-溴-2,3-二氢-6-羟基-1H-茚满-1-基]乙基]丙酰胺结构式

(S)-N-[2-[7-烯丙基...

(S)-N-[2-(5-溴-2,3-二氢-6-羟基-1H-茚满-1-基)乙基]丙酰胺结构式

(S)-N-[2-(5-溴-2...

~%

(S)-N-[2-[7-烯丙基-5-溴-2,3-二氢-6-羟基-1H-茚满-1-基]乙基]丙酰胺结构式

(S)-N-[2-[7-烯丙基...

(S)-N-[2-(5-Bromo-2,3-dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide结构式

(S)-N-[2-(5-Bro...

~%

(S)-N-[2-[7-烯丙基-5-溴-2,3-二氢-6-羟基-1H-茚满-1-基]乙基]丙酰胺结构式

(S)-N-[2-[7-烯丙基...

6-甲氧基-1-茚满酮结构式

6-甲氧基-1-茚满酮

~%

外消旋-N-[2-(2,3-二氢-6-甲氧基-1H-茚-1-基)乙基]丙酰胺结构式

外消旋-N-[2-(2,3-二...

(2E)-2-(2,3-Dihydro-6-methoxy-1H-inden-1-ylidene)acetonitrile结构式

(2E)-2-(2,3-Dih...

~%

外消旋-N-[2-(2,3-二氢-6-甲氧基-1H-茚-1-基)乙基]丙酰胺结构式

外消旋-N-[2-(2,3-二...

甲基磺酰氯结构式

甲基磺酰氯

(S)-N-[2-[2-[2,3-二氢-6-羟基-7-(2-羟乙基)-1H-茚满-1-基]乙基]丙酰胺结构式

(S)-N-[2-[2-[2,...

~86%

雷美替胺结构式

(E)-(1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-亚基)乙腈结构式

(E)-(1,6,7,8-四氢...

~79%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...

2,3-二氢苯并呋喃结构式

2,3-二氢苯并呋喃

~%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...

2,3-二氢苯并呋喃-5-甲醛结构式

2,3-二氢苯并呋喃-5-甲醛

~%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...

(E)-3-(2,3-二氢苯并呋喃-5-基)-2-丙烯酸乙酯结构式

(E)-3-(2,3-二氢苯并...

~%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...

1,2,6,7-四氢-8H-茚并[5,4-b]呋喃-8-酮结构式

1,2,6,7-四氢-8H-茚...

~%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...

3-(2,3-二氢苯并呋喃-5-基)丙酸乙酯结构式

3-(2,3-二氢苯并呋喃-5...

~%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...

3-(7-溴-2,3-二氢苯并呋喃-5-基)丙酸乙酯结构式

3-(7-溴-2,3-二氢苯并...

~%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...

未登录结构式

~%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...

4,5-二溴-1,2,6,7-四氢-8H-茚并[5,4-B]呋喃-8-酮结构式

4,5-二溴-1,2,6,7-...

~%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...

3-(6,7-二溴-2,3-二氢-1-苯并呋喃-5-基)丙酸结构式

3-(6,7-二溴-2,3-二...

~%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...

3-(6,7-二溴-2,3-二氢苯并呋喃-5-基)丙酸乙酯结构式

3-(6,7-二溴-2,3-二...

~%

2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-乙胺结构式

2,6,7,8-四氢-1H-茚...