Acyl transfer from carboxylate, carbonate, and thiocarbonate esters to enzymatic and nonenzymatic thiolates

C Gravel, D Lapierre, J Labelle…

文献索引：Gravel, Christian; Lapierre, Danielle; Labelle, Judith; Keillor, Jeffrey W. Canadian Journal of Chemistry, 2007 , vol. 85, # 3 p. 164 - 174

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被引用次数: 10

摘要

Transglutaminases (EC 2.3. 2.13)(TGases) catalyze calcium-dependent acyl transfer reactions between peptide-bound glutamine residues as acyl donors and peptide-bound lysine residues as acyl acceptors, resulting in the formation of intermolecular ϵ-(γ-glutamyl) lysine crosslinks. The mechanistic details of its" ping-pong" transamidation reaction remain unknown. In particular, few studies have been published probing the nucleophilicity of ...