Bioorganic & medicinal chemistry

Cyclic dibenzoylhydrazines reproducing the conformation of ecdysone agonists, RH-5849

T Toya, K Yamaguchi, Y Endo

文献索引：Toya, Tetsuya; Yamaguchi, Kentaro; Endo, Yasuyuki Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 4 p. 953 - 961

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被引用次数: 23

摘要

We have investigated the biologically active conformation of the non-steroidal ecdysone agonist, 1-tert-butyl-1, 2-dibenzoylhydrazine (RH-5849) by means of design, synthesis and conformational analysis of cyclic derivatives of RH-5849. Among the synthesized compounds, a 6-membered cyclic hydrazine bearing two benzoyl groups (5) exists in three conformational states in solution, and the major unsymmetrical conformer of 5 is similar to ...