Orally active and potent inhibitors of γ-aminobutyric acid uptake

…, WE Bondinell, PA Dandridge, JS Frazee…

文献索引：Ali, Fadia E.; Bondinell, William E.; Dandridge, Penelope A.; Frazee, James S.; Garvey, Eleanor; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 653 - 660

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被引用次数: 129

摘要

3-Pprolidineacetic acid (la), certain piperidinecarboxylic acids-Le., 3-piperidinecarboxylic acid (2a), 1, 2, 5, 6-tetrahydro-3-pyridinecarboxylic acid (3a), and cis-4-hydroxy-3- piperidinecarboxylic acid (4a)-cis-3-aminocyclohexanecarboxylic acid (5a, cis-3-ACHC), and y-aminobutyric acid (6a, GABA) itself are among the most potent inhibitors of [3H] GABA uptake by neurons and glia in vitro. These hydrophilic amino acids, however, do not ...