Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide …

V Monga, A Nayyar, B Vaitilingam, PB Palde…

文献索引：Monga, Vikramdeep; Nayyar, Amit; Vaitilingam, Balasubramanian; Palde, Prakash B.; Singh Jhamb, Sarbjit; Kaur, Sukhraj; Singh, Prati Pal; Jain, Rahul Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 24 p. 6465 - 6472

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被引用次数: 50

摘要

Additional structural modifications of the new chemical entity, 2, 8-dicyclopentyl-4- methylquinoline (DCMQ; MIC= 6.25 μg/mL, M. tuberculosis H37Rv) resulted in the synthesis of four new series of the ring-substituted quinolinecarbohydrazides (series 1–4) constituting 22 analogues. All new derivatives were evaluated for in vitro antimycobacterial activities against drug-sensitive M. tuberculosis H37Rv strain. Certain ring-substituted-2- ...