Trifluoromethanesulfonic acid, an unusually powerful catalyst for the Michael addition reaction of β-ketoesters under solvent-free conditions

…, K Arimura, T Ohishi, R Maruzasa

文献索引：Kotsuki, Hiyoshizo; Arimura, Koji; Ohishi, Takeshi; Maruzasa, Ryosuke Journal of Organic Chemistry, 1999 , vol. 64, # 10 p. 3770 - 3773

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被引用次数: 60

摘要

The Michael addition reaction is widely recognized as one of the most important carbon- carbon bond forming reactions in organic synthesis and can generally be carried out with a strong base. 1 However, the basecatalyzed method sometimes suffers from disadvantages of incompatibility with base-sensitive functionality and the occurrence of other side reactions such as autocondensations and retro-Michael type decompositions. To circumvent these ...