Tetrahedron letters

Efficient synthesis of 8, 11-dimethylene-bicyclo [5.3. 1] undecan-2-one

H Gu, WM Xu, TH Kinstle

文献索引：Gu, Haining; Xu, Wei Ming; Kinstle, Thomas H. Tetrahedron Letters, 2005 , vol. 46, # 38 p. 6449 - 6451

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被引用次数: 8

摘要

The bicyclo[5.3.1]undecane ring system is a substructure of naturally occurring taxanes. Among them, the most prominent representative compound is taxol, 1 a clinically useful anti-cancer drug. Due to its therapeutic potential and its limited availability, enormous efforts have been directed towards the chemical synthesis of taxol in the past decade. 2 The construction of the AB-ring core of taxol, which involves the bicyclo[5.3.1]undecane moiety, is among the most ...