Structure-function modeling of the interactions of N-alkyl-N-hydroxyanilines with rat hepatic aryl sulfotransferase IV

…, V Sharma, LC Pedersen, Y Kakuta…

文献索引：King, Roberta S.; Sharma, Vyas; Pedersen, Lars C.; Kakuta, Yoshimitsu; Negishi, Masahiko; Duffel, Michael W. Chemical Research in Toxicology, 2000 , vol. 13, # 12 p. 1251 - 1258

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被引用次数: 14

摘要

Although previous investigations have clearly shown that N-hydroxy arylamines and N- hydroxy heterocyclic amines are substrates for sulfotransferases, relatively little is known about which structural features of the N-hydroxy arylamines are important for sulfation to occur. The purpose of this investigation was to determine the extent to which secondary N- alkyl-N-hydroxy arylamines interact with aryl sulfotransferase (AST) IV (also known as ...