Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents

…, MA Mahran, AS Mehanna, DJ Abraham

文献索引：Randad, Ramnarayan S.; Mahran, Mona A.; Mehanna, Ahmed S.; Abraham, Donald J. Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 752 - 757

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被引用次数: 90

摘要

Three isomeric series of 2-(aryloxy)-2-methylpropionic acids were prepared and studied for their ability to decrease the oxygen affiiity of human hemoglobin A. The isomeric aryloxy groups included 44 [(aryloyl) amino] methyl] phenoxy, 4-(arylacetamido) phenoxy, and 44 ...