ChemMedChem

Pan??PPAR Agonists Based on the Resveratrol Scaffold: Biological Evaluation and Docking Studies

W Li, X He, W Shi, H Jia, B Zhong

文献索引：Li, Wei; He, Xinhua; Shi, Weiguo; Jia, Haoyan; Zhong, Bohua ChemMedChem, 2010 , vol. 5, # 12 p. 1977 - 1982

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被引用次数: 7

摘要

The peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily and consist of three receptor isoforms, PPARa, PPARg, and PPARd, which play important roles in carbohydrate and lipid metabolism. PPARa agonists such as fenofibrate, or the active metabolite fenofibric acid (1), are effective at lowering serum triglycerides and raising high-density lipoprotein (HDL) cholesterol.[1] PPARg has been ...