Organic & biomolecular chemistry

Kinetics and stereochemistry of hydrolysis of an N-(phenylacetyl)-α-hydroxyglycine ester catalyzed by serine β-lactamases and dd-peptidases

RB Pelto, RF Pratt

文献索引：Pelto, Ryan B.; Pratt Biochemistry, 2010 , vol. 49, # 49 p. 10496 - 10506

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摘要

The α-hydroxydepsipeptide 3-carboxyphenyl N-(phenylacetyl)-α-hydroxyglycinate (5) is a quite effective substrate of serine β-lactamases and low molecular mass DD-peptidases. The class C P99 and ampC β-lactamases catalyze the hydrolysis of both enantiomers of 5,