Unique carbamation of 2-(2-pyridyl)-1, 3-propanediol by phosgenation followed by ammonolysis

YM Choi, V Rosso, N Kucharczyk…

文献索引：Choi, Yong Moon; Rosso, Victor; Kucharczyk, Norbert; Sofia, R. Duane Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5764 - 5766

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被引用次数: 1

摘要

The phosgenation reaction mixture was 0.65 M in phosgene and 0.5 M in the functional group (FG) in substrate 4 in tetrahydrofuran (THF) unless otherwise indicated. The ammonolysis reaction mixture was 10 M in ammonia and 0.2 M in FG in substrate in THF. The addition of substrate to phosgene was carried out at both 0 and-30 OC for 0.25 h. The ammonolysis was carried out at both 0 and-70 OC for 0.25 h unlese otherwise indicated. ...