The Glaser–Hay Reaction: Optimization and Scope Based on 13C NMR Kinetics Experiments

MH Vilhelmsen, J Jensen, CG Tortzen…

文献索引：Vilhelmsen, Mie H.; Jensen, Jonas; Tortzen, Christian G.; Nielsen, Mogens B. European Journal of Organic Chemistry, 2013 , # 4 p. 701 - 711

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被引用次数: 24

摘要

Abstract The oxidative Glaser–Hay coupling of two terminal alkynes to furnish a butadiyne is a key reaction for acetylenic scaffolding. Although the reaction is performed under rather simple conditions [CuCl/TMEDA/O 2 (air)], the mechanism is still under debate. Herein we present detailed studies on the scope of this reaction by using both 13 C NMR and UV/Vis spectroscopic methods. The former method was used to study the kinetics of the coupling ...