The xanthene-9-spiro-4'-piperidine nucleus as a probe for opiate activity

…, J Horbury, ZS Matusiak, RJ Pearce…

文献索引：Galt, Ronald H. B.; Horbury, John; Matusiak, Zbigniew S.; Pearce, Robert J.; Shaw, John S. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2357 - 2362

全文：HTML全文

被引用次数: 20

摘要

Synthetic routes to xanthenespiropiperidines varied according to the substitution pattern required. Spiroalkylation of xanthenes with N-methyl-2, 2'-dichlorodiethylamine was particularly useful when a methyl substituent was required on the nitrogen atom. The parent compound 2 was prepared in one step from xanthene by this method. Suitably substituted xanthenes were synthesized by Ullman condensation of o-halobenzoic acids