Titanium-mediated cyclizations of. beta.-keto esters with acetals: a convenient route to 2-carbalkoxycycloalkenones

RL Funk, JF Fitzgerald, TA Olmstead…

文献索引：Funk, Raymond L.; Fitzgerald, John F.; Olmstead, Thomas A.; Para, Kim S.; Wos, John A. Journal of the American Chemical Society, 1993 , vol. 115, # 19 p. 8849 - 8850

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被引用次数: 27

摘要

The preparation of both carbocycles and heterocycles by Lewis acid-mediated cyclization reactions of acetals' has become a welldocumented synthetic strategy following the pioneering investigations of Johnson, who showed that acetals with appropriately positioned olefinic bonds undergo facile closure to mono-or polycyclic products. 2 More recently, extension of the Mukaiyama cross-aldol reaction (TiCl4-promoted condensation of ...