N-(heterocyclic alkyl) pyrido [2, 1-b] quinazoline-8-carboxamides as orally active antiallergy agents
…, P Levitan, J Lind, AF Welton, HJ Crowley…
文献索引：Tilley, Jefferson W.; Levitan, Paul; Lind, Joan; Welton, Ann F.; Crowley, Herman J.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 185 - 193
7 a. 5-Hexyn-2. ol.(C, H&PdCI2, NEIl b. H2, Pd (C). c Oxalyi chloride, NEI,, DMSO,-6OOC. d. NaH3BCN, H, NCI. e CH& from the corresponding cyanomethyl ester 31. The amide 19 was prepared by a Ritter reaction between the nitrile 6 and the tertiary alcohol 7 (method E). The preparation of the new heterocyclic alkylamines required as starting materials for these condensations not previously described8-l1 is summarized in Schemes 11-V. Thus 3- ...
![2-(1-methylethyl)-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid结构式](https://image.chemsrc.com/caspic/017/68701-10-0.png)
