A vHTS approach for the identification of β-adrenoceptor ligands

…, A Ammendola, K Wolf, T Wieber, J Schachtner…

文献索引：Tasler, Stefan; Baumgartner, Roland; Aschenbrenner, Andrea; Ammendola, Astrid; Wolf, Kristina; Wieber, Tanja; Schachtner, Josef; Blisse, Marcus; Quotschalla, Udo; Ney, Peter Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 11 p. 3399 - 3404

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被引用次数: 5

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Using a vHTS based on a pharmacophore alignment on known β3-adrenoceptor ligands, a set of intriguing β-adrenoceptor ligands was identified, optimization of which resulted in a selective and potent human β2-AR antagonist. ... Templates chosen for a pharmacophore alignment and ...