Potential antitumor agents. 12. 2-Formyl-4-aminophenylpyridine thiosemicarbazones

KC Agrawal, BA Booth, SM DeNuzzo…

文献索引：Agrawal,K.C. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, p. 368 - 371

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被引用次数: 23

摘要

20. NH2'P 14 and its ortho-and para-substituted amino derivatives 19 and 20, respectively. The results of these tests are shown in Table 11; antineoplastic activity was determined by measuring the effect of these agents on the survival time of mice bearing Sarcoma 180 ascites cells. Only the maximum prolongation of life produced by the administration of each material is listed, although a relatively wide range (10-60 mg/kg/day) of daily dosage ...