Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae
T Kudoh, CS Park, ST Lefurgy, M Sun, T Michels…
文献索引：Kudoh, Takashi; Park, Chan Sun; Lefurgy, Scott T.; Sun, Meihao; Michels, Theodore; Leyh, Thomas S.; Silverman, Richard B. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 3 p. 1124 - 1134
Survival of the human pathogen Streptococcus pneumoniae requires a functional mevalonate pathway, which produces isopentenyl diphosphate, the essential building block of isoprenoids. Flux through this pathway appears to be regulated at the mevalonate kinase (MK) step, which is strongly feedback-inhibited by diphosphomevalonate (DPM), the penultimate compound in the pathway. The human mevalonate pathway is not regulated ...
