... Volume: Page: ... a Reagents and conditions: (i) Fe, AcOH; (ii) crotonaldehyde, p-chloranil, HCl(aq), BuOH, Δ; (iii) H 2 , PdC, MeOH; (iv ... Given the health hazards associated with the use of DME as solvent, and that substitution is recommended wherever possible ...