Synthesis and pharmacological study of γ-carboxypropylamides of higher fatty acids

…, SM Alekseev, RP Evstigneeva, IK Sarycheva…

文献索引：Ashirova, V. E.; Alekseev, S. M.; Evstigneeva, R. P.; Sarycheva, I. K.; Morozov, I. S.; et al. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 7 p. 567 - 570 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 7 p. 817 - 819

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摘要

Laurie (IIa), linoleic (IIb), and linolenic (IIc) acids were chosen as the initial acids. The production of imidazolides of higher fatty acids (IIIa-c) was carried out in chloroform at room temperature with the aid of carbonyl diimidazole (IV) and was monitored using thin-layer chromatography (TLC) in system A. The reaction went to completion in 35-40 min. The conversion of imidazolides IIIa-c into target compounds Ia-c was carried out without ...