Synthesis of the 3-hydroxy-4-methyl derivative of amphetamine.

V Valenta, M Protiva

文献索引：Valenta; Protiva Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 7 p. 2240 - 2245

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被引用次数: 2

摘要

Abstract: p-Toluic acid was converted in seven steps to (3-methoxy-4-methylphenyl) acetonitrile (VIII) which underwent Claisen's reaction with ethyl acetate and subsequent acid hydrolysis to the phenylacetone derivative XI. Leuckart's reaction and alkaline hydrolysis of the product gave rise to 3-methoxy-4-methylamphetamine (XIII) which was demethylated with hydrobromic acid to the title compound I.