Verapamil analog with restricted molecular flexibility

…, MN Romanelli, S Scapecchi, E Teodori…

文献索引：Dei; Romanelli; Scapecchi; Teodori; Chiarini; Gualtieri Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2219 - 2225

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被引用次数: 27

摘要

Three analogues with restricted flexibility were designed to study the active conformation of verapamil during interaction with the slow calcium channel. Thus cis-and trans-l-(3, 4- dimethoxyphenyl)-4-[N-[2-(3, 4-dimethoxyphenyl) ethyl]-N-methylamino]-rl- cyclohexanecarbonitrile (5a and 5b), and 4-(3, 4-dimethoxyphenyl)-N-[2-(3, 4 dimethoxyphenyl) ethy1]-4-~ yanopiperidine (6), in which the verapamil structure is ...