The first total synthesis of lactonamycin, a hexacyclic antitumor antibiotic

…, H Tanaka, H Tsukagoshi, T Kashima, S Hosokawa

文献索引：Tatsuta, Kuniaki; Tanaka, Hiroaki; Tsukagoshi, Hitomi; Kashima, Takafumi; Hosokawa, Seijiro Tetrahedron Letters, 2010 , vol. 51, # 42 p. 5546 - 5549

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被引用次数: 19

摘要

The total synthesis of lactonamycin has been achieved. The synthesis includes sequential intramolecular conjugate addition of alcohols to the acetylenic ester, stereoselective glycosylation of the tertiary alcohol, and Michael–Dieckmann type cyclization with the thioester, by which the highly convergent route has been established.