(R)-(-)-and (S)-(+)-Synadenol: Synthesis, Absolute Configuration, and Enantioselectivity of Antiviral Effect x

…, A Hempel, N Camerman, A Camerman…

文献索引：Qui, Yao-Ling; Hempel, Andrew; Camerman, Norman; Camerman, Arthur; Geiser, Fiona; et al. J. Med. Chem., 1998 , vol. 41, # 26 p. 5257 - 5264

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被引用次数: 39

摘要

Synthesis of (R)-(-)-and (S)-(+)-synadenol (1a and 2a, 95-96% ee) is described. Racemic synadenol (1a+ 2a) was deaminated with adenosine deaminase to give (R)-(-)-synadenol (1a) and (S)-(+)-hypoxanthine derivative 5. Acetylation of the latter compound gave ...