Alkylation of diethyl acetamidomalonate with 5-bromo-N-phthaloyl-L-norvaline methyl ester (V) gives rise to a mixture of all three isomers of 2, 6-diaminopimelic acid. Alkylation of diethyl acetamidomalonate with ethyl 2-acetamido-5-bromo-2-ethoxycarbonyllevulinate (Xl) and subsequent hydrolysis of the resulting product gave 2, 6-diamino-4-oxopimelic acid (VIII) which in turn was converted to 4-oximino-(XIII), 4-amino-(XIV), and 4-hydroxY-2, 6- ...
