Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer

W Yao, J Zhuo, DM Burns, M Xu, C Zhang…

文献索引：Yoshiizumi, Kazuya; Yamamoto, Minoru; Miyasaka, Tomohiro; Ito, Yasuko; Kumihara, Hiroshi; Sawa, Masaaki; Kiyoi, Takao; Yamamoto, Takeshi; Nakajima, Fumio; Hirayama, Ryoichi; Kondo, Hirosato; Ishibushi, Etsuko; Ohmoto, Hiroshi; Inoue, Yoshimasa; Yoshino, Kohichiro Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 433 - 450

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被引用次数: 25

摘要

... We envisioned that this could be achieved by exploiting subtle differences within the S 1 ' subsite of the otherwise highly conserved active sites within the metalloprotease family. 9. At the inception of the project, Yoshiizumi et al. ...