Dual inhibition of the α-glucosidase and butyrylcholinesterase studied by Molecular Field Topology Analysis

F Jabeen, PV Oliferenko, AA Oliferenko…

文献索引：Jabeen, Farukh; Oliferenko, Polina V.; Oliferenko, Alexander A.; Pillai, Girinath G.; Ansari, Farzana Latif; Hall, C. Dennis; Katritzky, Alan R. European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 228 - 242

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被引用次数: 3

摘要

Abstract A striking dual inhibition of enzymes α-glucosidase and butyrylcholinesterase by small drug-like molecules, including 1, 4-disubstituted-1, 2, 3-triazoles, chalcones, and benzothiazepines, was rationalized with the help of Molecular Field Topology Analysis, a 3D QSAR technique similar to CoMFA. A common pharmacophore supported the concept of a link existing between type-2 diabetes mellitus and Alzheimer's disease. These findings ...