Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2, 5-disubstituted-dioxacycloalkanes

K Gu, L Bi, M Zhao, C Wang, J Ju, S Peng

文献索引：Gu, Keli; Bi, Lanrong; Zhao, Ming; Wang, Chao; Ju, Jingfang; Peng, Shiqi Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 4775 - 4799

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被引用次数: 10

摘要

A new class of 2, 5-disubstituted-dioxacycloalkanes were designed and synthesized via stereoselective synthetic method as cancer chemoprevention agents. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Some of these compounds exhibited comparable or better anti-inflammatory activities than that of aspirin suggesting that they can be further developed as potential ...