Medicinal chemical studies on antiplasmin drugs. 4. Chemical modification of trans-4-aminomethylcyclohexanecarboxylic acid and its effect on antiplasmin activity

…, S Funabashi, M Iwamoto, S Isoda…

文献索引：Okano; Inaoka; Funabashi; Iwamoto; Isoda Journal of medicinal chemistry, 1972 , vol. 15, # 3 p. 247 - 255

被引用次数: 23

摘要

A series of N-substituted derivatives, amides, and esters of trans-4- aminomethylcyclohexanecarboxylic acid (trans-AMCHA) were synthesized and evaluated for their antiplasmin activity. Among those, Ph ester derivatives were found to be superior to trans-AMCHA. 1n particular, a high order of the activity was achieved with para-substituted Ph esters. This paper reports the synthetic method, the antiplasmin activity, and the ...