Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS …

T Zhou, E Ohkoshi, Q Shi, KF Bastow, KH Lee

文献索引：Zhou, Ting; Ohkoshi, Emika; Shi, Qian; Bastow, Kenneth F.; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3219 - 3222

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被引用次数: 5

摘要

In this study, 19 dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl- dihydropyranoxanthone (DCX) derivatives, previously discovered as novel anti-HIV agents, were evaluated for their potential to reverse multi-drug resistance (MDR) in a cancer cell line over-expressing P-glycoprotein (P-gp). Seven compounds fully reversed resistance to vincristine (VCR) at 4μM, a 20-fold enhancement compared to the first generation ...