Tetrahedron Letters

Convenient synthesis of 4H-1, 2, 4-triazole-3-thiols using di-2-pyridylthionocarbonate

RF Deprez-Poulain, J Charton, V Leroux, BP Deprez

文献索引：Deprez-Poulain, Rebecca F.; Charton, Julie; Leroux, Virginie; Deprez, Benoit P. Tetrahedron Letters, 2007 , vol. 48, # 46 p. 8157 - 8162

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被引用次数: 15

摘要

We report here the convenient synthesis of 4H-1, 2, 4-triazole-3-thiols using di-2-pyridyl- thionocarbonate as the thiocarbonyl transfer reagent. This method is suitable for microplate parallel synthesis and produces samples in screening-ready condition. It uses two large sets of building-blocks: amines and hydrazides.