Synthesis and Anti??HIV Activity of Triazolo??Fused 3′, 5′??Cyclic Nucleoside Analogues Derived from an Intramolecular Huisgen 1, 3??Dipolar Cycloaddition
Abstract Triazolo-fused 3′, 5′-cyclic nucleoside analogues were synthesized by an intramolecular 1, 3-dipolar cycloaddition of nucleoside-derived azido-alkynes in a regio-and stereospecific manner. The thymine nucleoside base in these target compounds was transformed successfully into the corresponding 5-methylcytosine component. The synthesized compounds were examined in a MAGI assay for exploring the anti-HIV activity ...
