The Journal of Organic Chemistry

Synthesis of (.+-.)-okicenone and (.+-.)-aloesaponol III

BB Snider, Q Zhang

文献索引：Snider, Barry B.; Zhang, Qingwei Journal of Organic Chemistry, 1993 , vol. 58, # 11 p. 3185 - 3187

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被引用次数: 20

摘要

An analogous oxidative cyclization of 3b leads to 43% of 6b, la model for the synthesis of olivin, the aglycon of the aureolic acid antitumor antibiotic olivomycin. 2 The required substrate 3b is easily prepared in 68% yield by alkylation of the dianion of benzoyl acetone lb with 2.3 The antitumor antibiotic okicenone (14b), which was recently isolated from Streptomyces sp. KO-3599, shows cytocidal activity against mammalian tumor cells in vitro