Oxidative metabolism of 5-methoxy-N, N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes

S Narimatsu, R Yonemoto, K Saito, K Takaya…

文献索引：Narimatsu, Shizuo; Yonemoto, Rei; Saito, Keita; Takaya, Kazuo; Kumamoto, Takuya; Ishikawa, Tsutomu; Asanuma, Masato; Funada, Masahiko; Kiryu, Kimio; Naito, Shinsaku; Yoshida, Yuzo; Yamamoto, Shigeo; Hanioka, Nobumitsu Biochemical Pharmacology, 2006 , vol. 71, # 9 p. 1377 - 1385

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被引用次数: 27

摘要

In vitro quantitative studies of the oxidative metabolism of (5-methoxy-N, N- diisopropyltryptamine, 5-MeO-DIPT, Foxy) were performed using human liver microsomal fractions and recombinant CYP enzymes and synthetic 5-MeO-DIPT metabolites. 5-MeO- DIPT was mainly oxidized to O-demethylated (5-OH-DIPT) and N-deisopropylated (5-MeO- IPT) metabolites in pooled human liver microsomes. In kinetic studies, 5-MeO-DIPT O- ...