Activation mechanisms of mafosfamide and the role of thiols in cyclophosphamide metabolism

…, RF Borch, J Engel, U Niemeyer

文献索引：Kwon, Chul-Hoon; Borch, Richard F.; Engel, Jurgen; Niemeyer, Ulf Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 395 - 399

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被引用次数: 31

摘要

Department of Pharmacology, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, and Asta-Werke AG, Degussa Pharma Gruppe, Bielefeld, Federal Republic of Germany. Received June 9, 1986 cis-Mafosfamide (cis-5)(ASTA Z7557), a stable analogue of cis-4-hydroxycyclophosphamide (cis-%), undergoes rapid decomposition in aqueous phosphate buffer or plasma at pH 7.4 and 37 OC. The reaction ...