Organic letters

Palladium-Catalyzed Direct Intermolecular α-Arylation of Amides with Aryl Chlorides

B Zheng, T Jia, PJ Walsh

文献索引：Zheng, Bing; Jia, Tiezheng; Walsh, Patrick J. Organic Letters, 2013 , vol. 15, # 7 p. 1690 - 1693

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被引用次数: 42

摘要

An efficient catalytic system for the direct intermolecular α-arylation of acetamide derivatives with aryl chlorides is presented. Chemoselectivities up to 10: 1 in the mono-and diarylation of acetamides were achieved by careful selection of bases, solvents, and stoichiometry. Bis- arylated amides were prepared in up to 95% yield.