Synthesis of novel 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines as potential protein kinase inhibitors

…, M Schnürch, MD Mihovilovic, K Mereiter…

文献索引：Susnik, Marko P.; Schnuerch, Michael; Mihovilovic, Marko D.; Mereiter, Kurt; Stanetty, Peter Monatshefte fur Chemie, 2009 , vol. 140, # 4 p. 423 - 430

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被引用次数: 6

摘要

Abstract A short and efficient sequence for the synthesis of a series of 4-(2-amino-5- thiazolyl)-pyrimidine-2-amines was developed. 1-Phenyl-2-(6-pyrimidinyl)-ethanones, obtained via Weinreb's methodology, were used in a Hantzsch thiazole cyclization reaction, followed by introduction of the aniline moieties via nucleophilic substitution. Graphical abstract