Derivatives of imidazole. I. Synthesis and reactions of imidazo [1, 2-α] pyridines with analgesic, antiinflammatory, antipyretic, and anticonvulsant activity

L Almirante, L Polo, A Mugnaini…

文献索引：Almirante,L. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 305 - 312

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被引用次数: 143

摘要

A series of 42 derivatives of imidazo [1, 2-a] pyridine has been prepared and examiiied for analgesic, antiiiiflammatory, antipyretic, and muscle-relaxant activity. The results have been compared with those obtained under same conditions with acet, glsalicylic acid, aminopyriiie, pheiiylbutaao~ ie, aud chlortenosazirie. Several members of the series display high activities in a variety of pharmacological tests, the most iriterestiiig being 2-(p- ...