Differences between gastric antiulcer effects of trapencaine enantiomers

…, VŘ Nachname, Z Kupková, L Beneš…

文献索引：Nosal'Ova, Viera; Ricicova; Kupkova; Benes; Babul'Ova Pharmazie, 2003 , vol. 58, # 9 p. 657 - 660

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被引用次数: 1

摘要

The spatial arrangement of single stereoisomers may influence pharmacodynamic, pharmacokinetic and toxicological properties of a drug. Trapencaine (INN),(±)-trans-2- (pyrrolidin-1-yl) cyclohexyles-ter of 3-(n)-pentyloxycarbanilic acid, was developed as an antiulcer drug with gastroprotective, local anaesthetic and spasmolytic effects. Limited information is available about the potential pharmacodynamic differences of the ...