Design, synthesis, and biological evaluation of 4-(5-nitrofuran-2-yl) prop-2-en-1-one derivatives as potent antitubercular agents

NR Tawari, R Bairwa, MK Ray, MGR Rajan…

文献索引：Tawari, Nilesh R.; Bairwa, Ranjeet; Ray; Rajan; Degani, Mariam S. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 21 p. 6175 - 6178

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被引用次数: 9

摘要

Based on stereoelectronic feature analysis using density functional theory (DFT) at B3LYP/3- 21∗ G level, a series of 4-(5-nitrofuran-2-yl) prop-2-en-1-one derivatives with low LUMO energies (<− 0.10 eV); concentrated over the nitro group, furan moiety and α, β-unsaturated carbonyl bridge were envisaged as potential antitubercular agents. The target compounds were prepared by condensation of 5-nitro-2-furaldehyde with various ketones under acidic ...