European journal of medicinal chemistry

Design, synthesis, and antitubercular evaluation of novel series of 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1-pyrazolylcarbonyl-4- …

K Manna, YK Agrawal

文献索引：Manna, Kuntal; Agrawal, Yadvendra K. European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 3831 - 3839

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被引用次数: 54

摘要

Twenty-eight newer 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5- aryl-1-pyrazolylcarbonyl-4-oxo-naphthyridin analogs were synthesized by microwave irradiation method and evaluated for in-vitro and in-vivo antitubercular activity against multidrug-resistant M. tuberculosis stains. Structure–activity relationship study was carried out and found NO2 (o) substituted 3-benzofuran-5-aryl-1-pyrazolylcarbonyl-4-oxo- ...