Carbophilic 3??Component Cascades: Access to Complex Bioactive Cyclopropyl Diindolylmethanes

NM Groome, EE Elboray, MW Inman…

文献索引：Groome, Nigel M.; Elboray, Elghareeb E.; Inman, Martyn W.; Dondas, H. Ali; Phillips, Roger M.; Kilner, Colin; Grigg, Ronald Chemistry - A European Journal, 2013 , vol. 19, # 6 p. 2180 - 2184

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被引用次数: 5

摘要

Abstract Naturally occurring indole-3-carbinol and 3, 3-diindolylmethane show bioactivity in a number of disparate disease areas, including cancer, prompting substantial synthetic analogue activity. We describe a new approach to highly functionalised derivatives that starts from allene gas and proceeds via the combination of a three-component Pd 0- catalysed cascade with a one-pot, three-component carbophilic Pt II cascade linked to a ...