Synthesis and biological activity of unsaturated carboacyclic purine nucleoside analogs

…, CKH Tseng, VE Marquez

文献索引：Haines, David R.; Tseng, Christopher K. H.; Marquez, Victor E. Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 943 - 947

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被引用次数: 54

摘要

Two new carboacyclic nucleoside analogues, 9-[4-hydroxy-3-(hydroxymethyl)-2-butenyl] adenine(6) and 9-[4-hydroxy-3-(hydroxymethyl)-2-butenyl] guanine (51, modeled on the unsaturated carbocyclic nucleoside analogue neplanocin A (2), have been synthesized and tested for antiviral activity against HSV-2 and, in the case of 6, for activity against influenza and in vitro inhibition of S-adenosylhomocysteine hydrolase. The synthesis was ...