Summary A carboxylated side chain is easily introduced at the free position of 2-methyl-1, Pnaphthoquinone by alkylation with the peroxide derived from the half ester of a dibasic acid. Such naphthoquinonyl acids have been conjugated with sulfanilamides and also converted through diazoketones to naphthoquinonyl ketols possessing at least superficial structural relationships to cortical hormones and possibly to luciferin.