Bulletin of the Chemical Society of Japan

Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. XV. A Convenient Synthesis of 3, 5, 6-Trihydroxy-7-methoxyflavones and Revised Structures of …

H Tominaga, T Horie

文献索引：Tominaga; Horie Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 9 p. 2668 - 2675

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被引用次数: 6

摘要

A mixture of 6-hydroxy-3, 4′, 5, 7-tetramethoxy-and 5, 6-dihydroxy-3, 4′, 7- trimethoxyflavone was converted into 6-acetoxy-5-hydroxy-3, 4′, 7-trimethoxyflavone by acetylation and following dealkylation. The 3-methoxyl group in the tosylate of the 5- hydroxyflavone was selectively cleaved with anhydrous aluminum bromide in acetonitrile to give 6-acetoxy-3-hydroxy-4′, 7-dimethoxy-5-(tosyloxy) flavone. 3, 6-Dihydroxy-4′, 7- ...