Tetrahedron: Asymmetry

Lipase-based HPLC stationary phase: enantioselective synthesis of 2-substituted 1, 3-propanediol monoacetates

C Bertucci, A Petri, G Felix, B Perini, P Salvadori

文献索引：Bertucci, Carlo; Petri, Antonella; Felix, Guy; Perini, Benedetta; Salvadori, Piero Tetrahedron Asymmetry, 1999 , vol. 10, # 22 p. 4455 - 4462

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被引用次数: 30

摘要

Pseudomonas cepacia lipase (PCL) has been immobilized by coating the enzyme on an epoxysilica HPLC column. The biocatalyst has been successfully used for the preparation of both the enantiomers of 3-acetoxy-2-benzyl-propan-1-ol and of 3-acetoxy-2-methylpropan-1- ol. The immobilized enzyme is active after months of use either in aqueous or in organic media.