Tetrahedron letters

Synthesis of (+)-prelactone B

TK Chakraborty, S Tapadar

文献索引：Chakraborty, Tushar K.; Tapadar, Subhasish Tetrahedron Letters, 2003 , vol. 44, # 12 p. 2541 - 2543

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被引用次数: 38

摘要

Radical-mediated opening of a trisubstituted epoxy alcohol using cp2TiCl was followed by diastereoselective reduction of the resulting product with a centrally located methylene group, flanked on both sides by two chiral hydroxyl-bearing carbons, to build all the three chiral centers of (+)-prelactone B 1 in their desired stereochemistries leading to the total synthesis of the molecule.