Potent 3-spiropiperidine growth hormone secretagogues

…, G Morriello, K Prendergast, K Cheng, T Jacks…

文献索引：Yang, Lihu; Morriello, Greg; Prendergast, Kristine; Cheng, Kang; Jacks, Tom; Chan, Wanda W.-S.; Schleim, Klaus D.; Smith, Roy G.; Patchett, Arthur A. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 1 p. 107 - 112

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被引用次数: 50

摘要

Systematic SAR studies of the different regioisomers and homologues of the spiro (indane-1, 4′-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro (3H-1-benzopyran-2, 3′-piperidine) was found to afford secretagogues with low nanomolar in vitro activity.